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acinetobacter baumannii treatment

13 Nov 20
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297, 150–156. Colistin therapy combined with rifampin or fusidic acid seems to be the most effective for treating a MDR A. baumannii in a murine thigh-infection model (Fan et al., 2016). Gallium is a semi-metallic element in group 13 of the periodic table that binds to biological complexes containing Fe3+ and disrupts essential redox-driven biological processes (Bernstein, 1998). doi: 10.1007/s10096-016-2723-8, Anthony, K. B., Fishman, N. O., Linkin, D. R., Gasink, L. B., Edelstein, P. H., and Lautenbach, E. (2008). These results suggest that artilysins can be a treatment option for MDR A. baumannii. Wright, M. S., Haft, D. H., Harkins, D. M., Perez, F., Hujer, K. M., Bajaksouzian, S., et al. Agents 47, 380–385. Acinetobacter baumannii has become one of the most successful pathogens in modern healthcare because of its amazing ability to acquire antimicrobial resistance. Int. CL, JL, MP, and SL contributed to the conception and the design of the review and CL, JL, MP, KP, IB, YK, CC, BJ, and SL researched and wrote the review. Infect. doi: 10.1128/AAC.49.8.3198-3202.2005, Heritier, C., Poirel, L., and Nordmann, P. (2006). Cloning and nucleotide sequence analysis of a gene encoding an OXA-derived β-lactamase in Acinetobacter baumannii. Antimicrob. 6, 507. doi: 10.3389/fmicb.2015.00507, He, X., Lu, F., Yuan, F., Jiang, D., Zhao, P., Zhu, J., et al. Microbiol. doi: 10.1111/j.1469-0691.2005.01198.x, Pfeifer, Y., Wilharm, G., Zander, E., Wichelhaus, T. A., Gottig, S., Hunfeld, K. P., et al. (2010). doi: 10.1128/AAC.01139-06, Erridge, C., Moncayo-Nieto, O. L., Morgan, R., Young, M., and Poxton, I. R. (2007). doi: 10.1128/mBio.00312-12, Lin, L., Tan, B., Pantapalangkoor, P., Ho, T., Hujer, A. M., Taracila, M. A., et al. Esp. (2015). (2012). Clin. Novobiocin inhibits the antimicrobial resistance acquired through DNA damage-induced mutagenesis in Acinetobacter baumannii. Tigecycline for Acinetobacter baumannii infection: other considerations. High prevalence of the PER-1 gene among carbapenem-resistant Acinetobacter baumannii in Riyadh, Saudi Arabia. Similarly, β-aminoketone (MD3), an inhibitor of bacterial type I signal peptidases that cleaves the amino-terminal signal peptides of translocated proteins, shows a synergistic effect when combined with colistin against colistin-resistant A. baumannii strains (Martinez-Guitian et al., 2016). Antimicrob. This singular milestone puts us firmly on track towards meeting our near-term corporate objectives. Besides iron acquisition systems such as acinetobactin, the discovery of zinc and manganese acquisition systems in A. baumannii broadens our understanding of A. baumannii pathogenesis. Chemother. doi: 10.1128/AAC.01795-10, Borgeaud, S., Metzger, L. C., Scrignari, T., and Blokesch, M. (2015). Inactivation of phospholipase D diminishes Acinetobacter baumannii pathogenesis. Cephalosporinase over-expression resulting from insertion of ISAba1 in Acinetobacter baumannii. Another study revealed that a frameshift mutation in plsC, encoding 1-acyl-sn-glycerol-3-phosphate acyltransferase, is associated with decreased susceptibility to tigecycline (Li X. et al., 2015). Antimicrob. 8, 13859–13863. 56, 165–171. 195, 1335–1345. Immunol. doi: 10.1086/588051, Damier-Piolle, L., Magnet, S., Bremont, S., Lambert, T., and Courvalin, P. (2008). doi: 10.1128/AAC.45.12.3375-3380.2001, Mak, J. K., Kim, M. J., Pham, J., Tapsall, J., and White, P. A. doi: 10.1128/IAI.01184-12, Russo, T. A., Luke, N. R., Beanan, J. M., Olson, R., Sauberan, S. L., MacDonald, U., et al. (2011). Diagn. doi: 10.1128/AAC.00510-16, Martinez, T., Martinez, I., Vazquez, G. J., Aquino, E. E., and Robledo, I. E. (2016). doi: 10.1016/j.ijantimicag.2016.02.007, Merino, M., Acosta, J., Poza, M., Sanz, F., Beceiro, A., Chaves, F., et al. Agents Chemother. BioVersys is located in the Technologiepark in the thriving biotech hub of Basel. (2013). PLoS ONE 7:e37788. doi: 10.3390/ijerph10094274, Lee, C. R., Lee, J. H., Jeong, B. C., and Lee, S. H. (2013b). Front. Antimicrob. Virulence and immunomodulatory roles of bacterial outer membrane vesicles. doi: 10.1016/j.chom.2016.05.007, Navia, M. M., Ruiz, J., and Vila, J. In addition, polymyxin B is available for direct parenteral administration (Zavascki et al., 2007). Agents 27, 224–228. 67, 569–572. 56, 2504–2510. Imipenem treatment induces expression of important genes and phenotypes in a resistant Acinetobacter baumannii isolate. Microbiol. Furthermore, disrupting the ompA gene significantly decreases the minimal inhibitory concentrations (MICs) of several antibiotics (chloramphenicol, aztreonam, and nalidixic acid), suggesting that OmpA participates in the extrusion of antibiotics from the periplasmic space through the outer membrane and couples with inner membrane efflux systems (Smani et al., 2014). 60, 5101. doi: 10.1128/AAC.01124-16, Briers, Y., Walmagh, M., Van Puyenbroeck, V., Cornelissen, A., Cenens, W., Aertsen, A., et al. J. Clin. J. Clin. Characterization of a nosocomial outbreak caused by a multiresistant Acinetobacter baumannii strain with a carbapenem-hydrolyzing enzyme: high-level carbapenem resistance in A. baumannii is not due solely to the presence of β-lactamases. (2014). You are currently offline. doi: 10.1093/gbe/evu225, Traglia, G. M., Chua, K., Centron, D., Tolmasky, M. E., and Ramirez, M. S. (2014). doi: 10.1111/j.1469-0691.2007.01916.x, Rodriguez, C. H., De Ambrosio, A., Bajuk, M., Spinozzi, M., Nastro, M., Bombicino, K., et al. Immunomodulatory role of clarithromycin in Acinetobacter baumannii infection via formation of neutrophil extracellular traps. PLoS ONE 8:e70329. The EmrAB-TolC efflux pump is also present in A. baumannii where it conferred resistance to netilmicin, tobramycin, and imipenem (Nowak-Zaleska et al., 2016). Dis. (2016). Agents Chemother. First case of OXA-24-producing Acinetobacter baumannii in cattle from Reunion Island, France. Imipenem or meropenem combined with rose bengal shows synergistic effects for carbapenem-resistant A. baumannii clinical isolates (Chiu et al., 2016). PLA hydrolyzes fatty acids from the glycerol backbone, whereas PLC cleaves the phosphorylated head group from the phospholipid. Owing to the propensity of Acinetobacter to develop resistance to antibiotics, current treatment strategies remain limited. A number of A. baumannii resistance mechanisms are known, including enzymatic degradation of drugs, target modifications, multidrug efflux pumps, and permeability defects (Gordon and Wareham, 2010; Kim et al., 2012; Lin and Lan, 2014). Ther. Antimicrob. doi: 10.1128/AAC.00515-15, Chiu, C. H., Liu, Y. H., Wang, Y. C., Lee, Y. T., Kuo, S. C., Chen, T. L., et al. The FhaB/FhaC two-partner secretion system is involved in adhesion of Acinetobacter baumannii AbH12O-A2 strain. Impact of a cross-kingdom signaling molecule of Candida albicans on Acinetobacter baumannii physiology. BV100 is being developed for the treatment of serious hospital infections caused by Carbapenem resistant Acinetobacter baumannii. J. Bacteriol. Applications of MALDI-TOF mass spectrometry in clinical diagnostic microbiology. Jpn. 54, 2724–2727. The T6SS was first identified in Vibrio cholera and P. aeruginosa (Mougous et al., 2006; Pukatzki et al., 2006). Colistin is a key component of combination therapies used to treat MDR A. baumannii infections (Cai et al., 2012). Cell. FEBS Lett. Microbiol. Activity of tigecycline (GAR-936) against Acinetobacter baumannii strains, including those resistant to imipenem. Antibacterial activity of a novel peptide-modified lysin against Acinetobacter baumannii and Pseudomonas aeruginosa. Microb. Infect. Differences in phenotypic and genotypic traits against antimicrobial agents between Acinetobacter baumannii and Acinetobacter genomic species 13TU. Molecular characterization of metallo-β-lactamase-producing Acinetobacter baumannii and Acinetobacter genomospecies 3 from Korea: identification of two new integrons carrying the blaVIM-2 gene cassettes.

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